Sugar acids and derivatives
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (biotinylated, HEK293, his-avi) | >=95.0% | 20UG
Integrin alpha V beta 3 protein is a recombinant, biotinylated heterodimer derived from mouse and expressed in HEK293 cells. It carries C-His and C-Avi tags and is glycosylated, producing an apparent molecular weight of approximately 90-130 kDa. The protein is provided for in vitro studies of integrin-mediated ligand binding, cell adhesion, signaling, and biochemical assays.
- Recombinant mouse integrin heterodimer, biotinylated and tag-labeled.
- Expressed in HEK293 cells to preserve mammalian glycosylation.
- Suitable for ligand binding assays, ELISA, SPR, and pull-down experiments.
- Useful for cell adhesion and endothelial migration studies.
- Purity ≥95% as determined by reducing SDS-PAGE.
- Provided in assay-ready small-volume format.
Medchemexpress LLC Complement factor D-IN-2 | 1903742-34-6 | 99.33% | 574.43 | 25 MG
Complement factor D-IN-2 is an inhibitor of complement factor D, extracted from patent WO2015130838A1, compound 190. It targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway, and can be used for the research of autoimmune diseases.
- Reduces the excessive activation of complement factor D.
- Targets factor D and inhibits the complement cascade.
- Suitable for research of autoimmune diseases.
- For research use only.
Medchemexpress LLC Rehmannioside D | 81720-08-3 | MFCD30478904 | 99.9% | 686.61 g/mol | C27H42O20 | 10 MG
Rehmannioside D is a carotenoid glycoside isolated from the roots of Rehmannia glutinosa. Supplied as a 10 mg powder research reagent, it is used as an analytical standard and in biochemical studies of antioxidant activity and reactive oxygen species (ROS). Molecular formula C27H42O20; molecular weight 686.61 g/mol.
- Purity 99.9% suitable for analytical applications.
- Powder form, stable under recommended storage conditions.
- Useful in antioxidant and ROS pathway studies.
- Provided as a 10 MG vial for small-scale experiments.
- Identified by CAS number 81720-08-3 for unambiguous chemical identification.
Medchemexpress LLC PROTAC BET degrader-1 | 2093386-22-0 | 99.4% | 871.90 g·mol⁻¹ | C44H45N11O9 | 25 MG
PROTAC BET Degrader-1 is a proteolysis-targeting chimera that links Cereblon and BET ligands to induce degradation of BET family proteins BRD2, BRD3, and BRD4 at low concentrations. It is supplied as a light yellow solid for research use only.
- Degrades BRD2, BRD3, and BRD4 at low nanomolar concentrations.
- High purity suitable for biochemical and cell-based assays.
- Readily soluble in DMSO; protocols provided for in vivo formulations.
- Stable when stored as powder at -20 °C and in solvent at -80 °C.
Medchemexpress LLC D-KLVFFA | 342877-55-8 | 99.3% | 723.90 | 10 MG
D-KLVFFA is an inhibitor of Amyloid-β assembly, with an IC50 of 2.6 μM. It can be utilized in Alzheimer's disease studies, offering insights into amyloid-beta aggregation pathways.
- Inhibits amyloid-β assembly
- Useful in Alzheimer's disease studies
- Molecular weight of 723.90
- Purity of 99.3%
Medchemexpress LLC Cdk1/Cyc B-IN-1 | 2459916-56-2 | 98.5% | 353.85 | 50 MG
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. It triggers apoptosis and G2/M cell cycle arrest and demonstrates broad-spectrum cytotoxic action against cancer cell lines. In vitro, it is soluble in DMSO at 100 mg/mL.
- Induces apoptosis and G2/M cell cycle arrest
- Exhibits cytotoxic activity against HCT-116 cells (IC50 of 5.33 ± 0.69 μM)
- Exhibits cytotoxic activity against WI-38 cells (IC50 of 21.69 ± 1.04 μM)
- Shows antiproliferative activity against various human cancer cell lines
Medchemexpress LLC 4-Methylumbelliferyl 10mM 1mL
4-Methylumbelliferyl octanoate is a octoate 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase[1]
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (HEK293, His) | >95.0% | 50UG
Integrin alpha V beta 3 protein, mouse (HEK293, His) is a recombinant heterodimeric integrin complex produced in HEK293 cells and supplied with a C-terminal His tag. It is intended for research use to support studies of integrin-mediated cell adhesion, signaling, and ligand interactions.
- Recombinant heterodimeric integrin complex (ITGAV:ITGB3).
- Expressed in HEK293 mammalian cells.
- C-terminal His tag for detection and purification.
- Purity greater than 95% as determined by reducing Tris-Bis PAGE.
- Observed molecular weight 90-130 kDa.
- Available in small-scale sizes suitable for biochemical assays (20 μg, 50 μg, 100 μg).
- For research use only; not for therapeutic or diagnostic use.
![Medchemexpress LLC 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-thiazolo[4,5-d]pyrimidine-2-thione | 2459916-56-2 | 98.5% | 353.85 g/mol | C14H12ClN3O2S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286978.png-250.jpg)
Medchemexpress LLC 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-thiazolo[4,5-d]pyrimidine-2-thione | 2459916-56-2 | 98.5% | 353.85 g/mol | C14H12ClN3O2S2 | 10 MG
CDK1/Cyc B-IN-1 is a small-molecule inhibitor selective for the CDK1-cyclin B kinase complex. It inhibits CDK1-cyclin B activity (reported IC50 ≈97 nM) and induces G2/M cell-cycle arrest and apoptosis in cancer cell lines. The compound is supplied as a solid with high purity and is used in biochemical and cellular studies of cell-cycle regulation.
- Selective CDK1-cyclin B inhibitor with reported IC50 ≈97 nM.
- Induces G2/M cell-cycle arrest and apoptosis in cell lines.
- Suitable for biochemical kinase assays and cell-based studies.
- High supplied purity for reproducible results.
- Soluble in DMSO at 100 mg/mL; use newly opened DMSO.
- Stable as a powder under recommended cold storage conditions.
Medchemexpress LLC (2R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide | 1147883-03-1 | 99.3% | 265.30 g/mol | C14H19NO4 | 25MG
EPI-589 is a redox-active small-molecule neuroprotective compound used in research on oxidative stress and neurodegenerative disorders. Supplied as a light yellow powder, it is formulated for both in vitro and in vivo experimentation and is readily soluble in DMSO with recommended vehicle formulations for animal dosing. The compound is characterized and shelf-stable under appropriate storage conditions.
- High purity: 99.3%.
- Chemical formula: C14H19NO4.
- Molecular weight: 265.30 g/mol.
- Form: solid powder, light yellow to yellow.
- In vitro solubility: DMSO 100 mg/mL.
- Recommended in vivo vehicles and clear solution ≥ 2.5 mg/mL.
- Storage: powder at -20°C (long term) or 4°C (short term).
Medchemexpress LLC Protac α-synuclein degrader 5 | 2781922-42-5 | 100.0% | 767.78 g/mol | C39H41N7O10 | 10 MG
PROTAC α-synuclein degrader 5 is a small-molecule PROTAC designed to selectively target and promote degradation of α-synuclein aggregates in cellular models. Supplied as a high-purity solid for preclinical research, it shows dose-dependent activity in fibril-seeding assays and is formulated for in vitro and in vivo use.
- Selective degradation of α-synuclein aggregates (DC50 ≈ 7.5 μM, Dmax 89%).
- Demonstrated reduction of aggregates within 48 hours in PFF seeding cell models.
- High-purity solid suitable for biochemical and cellular assays.
- High solubility in DMSO for in vitro applications (≥100 mg/mL).
- Compatible with in vivo formulation protocols and frozen storage for stability.
![Apexbio Technology LLC vitamin D binding protein precursor (353-363) [Homo sapiens] 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096705.png-250.jpg)
Apexbio Technology LLC vitamin D binding protein precursor (353-363) [Homo sapiens] 10mg
Vitamin D binding protein precursor 353-363 is a serum glycoprotein fragment derived from Homo sapiens It is associated with vitamin D binding protein (DBP) a plasma protein that binds vitamin D metabolites and actin monomers mediating transport in the bloodstream and regulation of extracellular actin levels DBP is present on surfaces of various immune cell types including B and T lymphocytes as well as placental cytotrophoblasts Based on these pharmacological properties vitamin D binding protein precursor 353-363 holds research potential in studies of vitamin D metabolism immune regulation and cytoskeletal interactions
Selleck Chemical LLC N-Acetylneuraminic acid S4792-1g
N-Acetylneuraminic acid (Neu5Ac NeuAc Acido aceneuramico Acide aceneuramique Acidium aceneuramicum Sialic acid NANA) is the predominant sialic acid found in mammalian cells Sialic acids are negatively charged monosaccharides attached to the end of sugar chains giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes
